Here in Ann Arbor we are blessed by having some very good indie bookstores, as well as good used bookstores, and some big box stores. The problem is that the good used stores and most of the good indie stores, as well as the flagship world headquarters Borders store are all downtown, where parking is a bite on the butt.
So, unless I am downtown to go to a concert or the like, I usually go to the big box Barnes and Noble, or the mall Borders. The mall Borders has a better science fiction/fantasy selection, but the Barnes and Noble is on the way to work, so I usually end up there...
I did not know how good I had it, until my son went off to college in small city Indiana. They have a tiny selection abomination of a store called Books A Million at the mall; they have textbook stores near the university; and if there are any decent used bookstores (and you would think that enough kids go to that univeristy that there would be at least one great used bookstore) I sure have not been able to find them.
One of the things my son does when he comes home on breaks is to go to one of the big box bookstores in Ann Arbor so he can browse in the history section, and get a chance to sit down and look through the books without someone bugging him every three minutes "Do you need any help?" like they do at the textbook stores in Muncie.
My friends have all been after me to move down there and open a good used and/or indie bookstore, as there is a clear and pressing need.